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目的研究妊娠期高血压患者超敏C反应蛋白(hs-CRP)的水平以及hs-CRP与妊娠期高血压的相关性。方法选择2010年7月—2012年12月间进行诊治的80例妊娠期高血压患者,并选择同一时期晚期健康妊娠的44例孕妇,比较两组孕妇的超敏C反应蛋白水平,同时对其临床意义进行分析。结果对照组患者hs-CRP水平为(2.05±0.88)mg/L,HDCP组为(5.78±2.28)mg/L,HDCP组患者血清hs-CRP水平明显高于健康对照组,差异有统计学意义(P<0.05)。HDCP组妊娠期高血压、轻度子痫前期、重度子痫前期的血清血清hs-CRP水平差异较为显著,有统计学意义(P<0.05)。同时随着疾病的发展,其血清hs-CRP水平也会逐渐增长。结论血清CRP能够对妊娠期高血压疾病的发生发展有一定的影响,同时还会损伤妊娠期高血压患者肾脏的功能。血清hs-CRP不但能够对妊娠期高血压疾病的变化进行真实的反应,同时还能够对妊娠期高血压疾病患者的早期肾损伤进行评价。
Objective To investigate the level of hs-CRP and the correlation between hs-CRP and gestational hypertension in patients with gestational hypertension. Methods Eighty patients with gestational hypertension who were diagnosed and treated between July 2010 and December 2012 were enrolled. Forty-four pregnant women of the same period were selected as healthy pregnant women. The levels of high-sensitivity C-reactive protein in the two groups were compared. Meanwhile, Clinical significance analysis. Results The hs-CRP level was (2.05 ± 0.88) mg / L in control group and (5.78 ± 2.28) mg / L in HDCP group, and the serum hs-CRP level in HDCP group was significantly higher than that in healthy control group (P <0.05). HDCP group gestational hypertension, mild preeclampsia, severe serum preeclampsia serum hs-CRP levels were significantly different, with statistical significance (P <0.05). At the same time as the disease progresses, its serum hs-CRP level will gradually increase. Conclusions Serum CRP can exert some influence on the development of hypertensive disorders in pregnancy, at the same time it can damage the function of kidney in hypertensive patients during pregnancy. Serum hs-CRP not only realizes the real response to the changes of hypertensive disorders in pregnancy, but also can evaluate the early renal damage in patients with hypertensive disorders during pregnancy.