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目的探讨子宫内膜异位症(EM)患者血清与腹腔液中CA125的表达水平与意义。方法收集EM患者121例作为观察组,收集非EM但需要行妇科手术的患者85例作为对照组,术前检测两组患者血清CA125,术中抽取腹腔液检测CA125水平,进行对比分析。结果 EM患者血清CA125水平明显高于对照组[(91.24±15.29)k U/L VS(16.12±6.28)k U/L)],差异有统计学意义(P<0.05);EM患者血清CA125表达阳性率为80.17%,对照组患者血清CA125表达阳性率为0.00%,两组比较差异有统计学意义(P<0.05);EM患者腹腔液CA125水平明显高于对照组[(2 123.6±214.3)k U/L VS(715.3±98.5)k U/L],差异有统计学意义(P<0.05);EM患者腹腔液CA125表达阳性率为92.56%,对照组患者腹腔液CA125表达阳性率为0.00%,两组比较差异有统计学意义(P<0.05)。结论腹腔液中CA125的水平对EM的诊断敏感,具有较高临床价值。
Objective To investigate the expression and significance of CA125 in serum and peritoneal fluid of patients with endometriosis (EM). Methods A total of 121 patients with EM were enrolled in this study. A total of 85 non-EM patients were enrolled in this study. Serum CA125 levels were measured before operation in both groups. Peritoneal fluid was taken for CA125 measurement. Results The level of serum CA125 in patients with EM was significantly higher than that in controls [(91.24 ± 15.29) kU / L vs (16.12 ± 6.28) kU / L), the difference was statistically significant (P <0.05) The positive rate of CA125 in the control group was 0.00%, the difference was statistically significant (P <0.05). The CA125 level in peritoneal fluid of EM patients was significantly higher than that of the control group [(2 123.6 ± 214.3) (P <0.05). The positive rate of CA125 expression in peritoneal fluid of patients with EM was 92.56%, and the positive rate of peritoneal CA125 expression in control group was 0.00 %, The difference between the two groups was statistically significant (P <0.05). Conclusion The level of CA125 in peritoneal fluid is sensitive to the diagnosis of EM and has high clinical value.