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在50年代中期,由于绒毛膜肿瘤对于化疗效果很好,引起了妇科肿瘤学家们的重视。近20年,多数病人除了手术以外,化疗也成为一种主要的治疗方法。在这期间里,对于这种肿瘤已积累了丰富的资料,不仅在病史特征而且也包括内分泌功能方面的资料。关于绒毛膜肿瘤产生激素的特性方面的知识已在增长,特别是对滋养叶细胞所产生的多种多肽物及类固醇物质的敏感性及特异性测定系统方面的发展。本文将复习绒毛膜肿瘤的内分泌功能,并说明这些试验在诊断、治疗及随访中的应用。
In the mid-1950s, as choriocarcinomas performed well for chemotherapy, they attracted the attention of gynecologic oncologists. In the last 20 years, in addition to surgery, most patients have also become a majorstay of treatment. During this period, a wealth of information has been accumulated for this tumor, not only in the history but also in the endocrine function. Knowledge of the hormonal properties of chorionic tumors has increased, particularly in the development of sensitive and specific assay systems for various polypeptide and steroid substances produced by trophoblastic cells. This article reviews the endocrine function of choriocarcinoma and describes the use of these tests in diagnosis, treatment, and follow-up.