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目的观察消癥汤治疗子宫肌瘤的临床疗效。方法将260例患者随机分为治疗组和对照组,每组130例,治疗组服用消癥汤,每日1剂分2次服,对照组口服米非司酮每日1次25mg,两组均治疗3个月并进行1年后随访。观察治疗前后及1年后子宫及子宫肌瘤大小,同时观察肌瘤大小对疗效的影响;并于治疗前后对患者进行焦虑程度(SAS)评分及血红蛋白水平测定。结果治疗后两组患者子宫及子宫肌瘤大小均较治疗前明显减小(P<0.05),1年后随访治疗组患者子宫及子宫肌瘤大小明显小于对照组(P<0.05);治疗后两组均能减小最大子宫肌瘤直径(P<0.05),1年后治疗组最大子宫肌瘤直径均明显低于对照组(P<0.05);治疗组治疗后患者的SAS评分降低、血红蛋白水平升高(P<0.05或P<0.01);治疗组治疗后SAS评分、血红蛋白水平与对照组比较差异有统计学意义(P<0.05或P<0.01)。治疗组总有效率86.92%,对照组总有效率75.38%,治疗组患者临床疗效优于对照组(P<0.05)。结论消癥汤和米非司酮均有较好的缩小子宫和子宫肌瘤的作用,但在消除焦虑、改善贫血方面消癥汤优于米非司酮,且治疗后子宫肌瘤复发率低于米非司酮。
Objective To observe the clinical efficacy of Xiaozheng Tang in treating uterine fibroids. Methods 260 patients were randomly divided into treatment group and control group, with 130 cases in each group. The treatment group took Xiaoshi Soup, one dose of 2 times a day, the control group took mifepristone once a day 25mg, two groups All patients were treated for 3 months and followed up for 1 year. The size of uterine and uterine fibroids was observed before and after 1 year and 1 year after treatment. At the same time, the effect of fibroids size on the curative effect was observed. The patients’ anxiety (SAS) score and hemoglobin level were measured before and after treatment. Results After treatment, the size of uterus and uterine fibroids in both groups were significantly decreased (P <0.05), and the size of uterus and uterine fibroids in the follow-up group after 1 year was significantly smaller than that in the control group (P <0.05). After treatment The diameter of the largest uterine fibroids in the treatment group was significantly lower than that in the control group after one year (P <0.05). The SAS scores of the patients in the treatment group decreased and the hemoglobin (P <0.05 or P <0.01). SAS score and hemoglobin level in the treatment group were significantly different from those in the control group (P <0.05 or P <0.01). The total effective rate was 86.92% in the treatment group and 75.38% in the control group. The clinical efficacy of the treatment group was better than that of the control group (P <0.05). Conclusion Xiaoshi Decoction and mifepristone have a better role in narrowing the uterus and uterine fibroids, but in eliminating anxiety and improving anemia, Xiao Shi Tang is better than mifepristone, and the recurrence rate of uterine fibroids after treatment is low In mifepristone.