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目的探讨乳糖酶治疗轮状病毒肠炎患儿中乳糖酶缺乏的临床疗效。方法对本院儿科2013年1月~2013年12月腹泻患儿进行轮状病毒检测,应用改良斑氏法作粪还原糖及pH值测定,其中还原糖2+~3+或还原糖+,pH值<5.5作为研究对象,随机分为治疗组和对照组,对照组给予补液、纠酸、补锌、补充活菌制剂、平常饮食等综合治疗,治疗组在对照组基础上加用乳糖酶口服。结果治疗组总有效率96.2%,对照组总有效率80.4%。经χ2检验,两组总有效率比较差异具有统计学意义(P<0.01),治疗组平均痊愈天数为(4.13±1.22)d,对照组平均痊愈天数为(5.25±1.56)d。两组经t检验,差异具有统计学意义(P<0.01)。结论乳糖酶治疗轮状病毒肠炎继发乳糖酶缺乏疗效可靠,且无任何副作用,可作为治疗轮状病毒肠炎的常规用药。
Objective To investigate the clinical efficacy of lactase in the treatment of lactase deficiency in children with rotavirus enteritis. Methods The rotavirus was detected in children with diarrhea from January 2013 to December 2013 in our hospital. The improved method was used to make fecal reducing sugars and pH values, in which the reducing sugar (2 + -3 +) or reducing sugar + pH value <5.5 as the research object, were randomly divided into treatment group and control group, the control group given rehydration, acid correction, zinc supplementation, supplemented with viable preparations, diet and other general treatment, the treatment group on the basis of the control group plus lactase oral. Results The total effective rate was 96.2% in the treatment group and 80.4% in the control group. The χ2 test showed that the total effective rate of the two groups was statistically significant (P <0.01), the average number of days cured was (4.13 ± 1.22) days in the treatment group and (5.25 ± 1.56) days in the control group. Two groups by t test, the difference was statistically significant (P <0.01). Conclusion lactase treatment of rotavirus enteritis secondary lactase deficiency reliable, and without any side effects, can be used as a routine treatment of rotavirus enteritis.