类风湿关节炎(RA)是以累及周围关节为主的自身免疫性疾病,致残率很高。关节腔内注射治疗具有安全性高、全身不良反应小、有效浓度高等优点。目前关节腔内研究的主要有糖皮质激素、抗代谢药物、生物制剂、透明质酸以及中药制剂等。有文献报道,三氧化二砷可促进RA滑膜细胞凋亡,有望为RA的治疗开辟一条新的途径。 Rheumatoid arthritis (RA) is an autoimmune disease that affects the surrounding joints and has a high rate of disability. Intra-articular injection has the advantages of high safety, little adverse systemic reaction and high effective concentration. At present, articular cavity studies mainly include glucocorticoids, antimetabolites, biological agents, hyaluronic acid, and traditional Chinese medicine preparations. It has been reported in the literature that arsenic trioxide can promote the apoptosis of RA synovial cells and is expected to open up a new way for the treatment of RA.