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目的探讨广东地区汉族人人类白细胞抗原-DQB1(humanleukocyteantigen-DQB1,HLA-DQB1)等位基因与十二指肠溃疡(duodenalulcer,DU)的遗传关联。方法应用聚合酶链反应-序列特异性引物核苷酸分型技术,对105例DU患者、105名正常人的HLA-DQB1等位基因进行分析。结果DU患者HLA-DQB1*0602等位基因频率与正常对照组比较明显增高,差异有统计学意义(P=0.001,RR=4.533,Pc=0.014)。结论HLA-DQB1*0602与十二指肠溃疡有一定关联,HLA-DQB1等位基因分布在十二指肠溃疡患者与正常人之间存在着差异。
Objective To investigate the genetic association of human leukocyte antigen-DQB1 (HLA-DQB1) allele and duodenal ulcer (DU) in Han nationality in Guangdong Province. Methods The HLA-DQB1 alleles of 105 DU patients and 105 normal subjects were analyzed by polymerase chain reaction-sequence-specific primer nucleotide analysis. Results The frequency of allele HLA-DQB1 * 0602 in DU patients was significantly higher than that in normal controls (P = 0.001, RR = 4.533, Pc = 0.014). Conclusion HLA-DQB1 * 0602 is associated with duodenal ulcer. HLA-DQB1 allele distribution is different between patients with duodenal ulcer and normal subjects.