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疟疾是一种严重危害人类健康的疾病。来自疟疾流行区及动物实验的结果都证明感染疟原虫后机体可以产生一定的保护性免疫,说明疟原虫有保护性抗原,并且有了制备疟原虫疫苗的可能性。为了控制疟疾制备有效的疫苗,很多科学家对多种疟原虫的抗原进行分析,筛选保护性抗原。并对抗原的结构、理化性质、合成、加工和代谢进行了研究。在疟疾生活史中,子孢子、配子体、裂殖子和感染红细胞都直接暴露于宿主的免疫系统,这是疟原虫生活史中的薄弱环节。因此,抗原分析工作也集中于子孢子、裂殖子、感染红细胞和配子上。近年来,由于单克隆抗体
Malaria is a disease that seriously affects human health. Results from malaria-endemic areas and animal experiments have shown that the body can produce some protective immunity after infection with Plasmodium, indicating that the malaria parasite has a protective antigen and the possibility of preparing a vaccine against Plasmodium. In order to control effective malaria vaccine preparation, many scientists analyze the antigen of a variety of malaria parasites and screen for protective antigens. The structure, physicochemical properties, synthesis, processing and metabolism of the antigen were studied. In the life history of malaria, sporozoites, gametocytes, merozoites and infected erythrocytes are all directly exposed to the host’s immune system, which is the weakest link in the life history of Plasmodium. Therefore, antigen analysis is also focused on sporozoites, merozoites, infected red blood cells and gametes. In recent years, due to the monoclonal antibody