论文部分内容阅读
目的探讨胃间质瘤的预后。方法回顾性分析1994~2004年67例胃间质瘤临床病理资料,以新的间质瘤分级法F lecther分级。采用kap lan-m e ier法绘制生存曲线(log-rank检验)和cox多因素回归分析对该组病例预后分析。结果根据F lecther风险分级,极低风险5例(7.5%),低风险11例(16.4%),中风险29例(43.3%),高风险22例(32.8%),术后生存率随分级依次递减(P=0.0001),比较肿瘤大小,核分裂相(>5,≤5),是否伴发远处转移,是否伴发淋巴结转移差异具有显著性(P<0.05),根治性手术与非根治性手术组比较差异具有显著性(P=0.04)。而肿瘤位置、年龄、性别、免疫组化表达情况、是否联合脏器切除差异无显著性。结论用F lecther分级对胃间质瘤分级评价更为科学合理。根治性手术是治疗胃间质瘤最佳选择,核分裂相是判断预后的独立预后因素。
Objective To investigate the prognosis of gastric stromal tumors. Methods The clinical data of 67 cases of gastric stromal tumors from 1994 to 2004 were retrospectively analyzed. F lecther was graded by the new classification of stromal tumors. The Kaplan-Meier method was used to draw the survival curve (log-rank test) and cox multivariate regression analysis of the prognosis of the group. Results According to F lecther risk classification, there were 5 cases (7.5%) with very low risk, 11 cases (16.4%) with low risk, 29 cases (43.3%) with moderate risk and 22 cases (32.8%) with high risk. (P = 0.0001). The differences of tumor size, mitotic phase (> 5, ≤5), distant metastasis and lymph node metastasis were significant (P <0.05). The difference between radical surgery and non-radical treatment The difference in sex surgery group was significant (P = 0.04). The tumor location, age, gender, immunohistochemical expression, whether the combined organ resection was no significant difference. Conclusion F lecther classification of gastric stromal tumor grading evaluation is more scientific and rational. Radical surgery is the best choice for the treatment of gastric stromal tumors, mitotic phase is an independent prognostic prognostic factors.