论文部分内容阅读
近几年,人们发现正常非肿瘤机体的淋巴细胞对有些肿瘤靶细胞也有杀伤作用。由于它的杀伤作用既不需要特异性抗体的存在,又不需要预先用肿瘤抗原刺激,故称自然杀伤细胞(NKG,Nature killer cell),又称自发性淋巴细胞介导的细胞毒(SLMG,Spontaneous Lymphocyte-mediated cytotoxicity)。本文主要介绍NK细胞的有关性质及NK细胞与抗肿瘤免疫的关系。 NK细胞的一般性质 NK细胞不是成熟的T细胞,因为nude小鼠(先天性无胸腺、无毛小鼠)的T淋巴细胞分化成熟过程受阻,缺乏T细胞介导的各种免
In recent years, it has been found that normal non-tumorous lymphocytes also kill some tumor target cells. Because of its killing effect, it does not require the presence of specific antibodies and does not need to be stimulated with tumor antigens in advance. Therefore, natural killer cells (NKGs), also called spontaneous lymphocyte-mediated cytotoxicity (SLMG, Spontaneous Lymphocyte-mediated cytotoxicity. This article describes the nature of NK cells and NK cells and anti-tumor immunity. The general nature of NK cells NK cells are not mature T cells because the maturation of T lymphocytes in nude mice (congenital athymic, hairless mice) is blocked by the lack of T cell mediated immunity