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目的：探讨人心钠素（ｈＡＮＰ）对妊高征患者视网膜中动脉（ＣＲＡ）及脐动脉（ＵＡ）血流的影响．方法：对３２例重度妊高征患者随机分为心钠素治疗组（２０例）及安慰剂对照组（１２例），分别给予５０ｇ／Ｌ葡萄糖１００ｍＬ加ｈＡＮＰⅢ６μｇ／ｋｇ及５０ｇ／Ｌ葡萄糖１００ｍＬ静滴３０ｍｉｎ，应用彩色多普勒超声测定用药前、后ＣＲＡ及ＵＡ血流阻力指标．结果：ｈＡＮＰ显著降低ＣＲＡ脉搏指数（ＰＩ）、阻力指数（ＲＩ）、ＵＡ收缩期与舒张期血流速度（Ｓ／Ｄ）比值（分别Ｐ＜０．０１）及ＵＡＰＩ、ＲＩ（分别Ｐ＜０．０５）．安慰剂组ＣＲＡ及ＵＡ血流阻力指标均无显著变化．结论：ｈＡＮＰ降低妊高征视网膜动脉及脐动脉血流阻力．提示：ｈＡＮＰ可能具有改善妊高征中枢及胎盘－胎儿循环作用．
Objective: To investigate the effect of human plasma atrial natriuretic peptide (hANP) on the blood flow of the middle retinal artery (CRA) and umbilical artery (UA) in PIH patients. Methods: Thirty-two cases of severe PIH were randomly divided into three groups: atrial natriuretic peptide (20 cases) and placebo control group (12 cases). 50 mg / L glucose 100 mL plus hANP Ⅲ 6 μg / kg and 50 g / Dropping 30min, using color Doppler ultrasound before and after medication CRA and UA blood flow resistance index. Results: hANP significantly decreased the PI, RI, S / D ratio (P <0.01, respectively) and UAPI and RI (P <0 .05). The placebo group CRA and UA blood flow resistance index no significant change. Conclusion: hANP reduces the resistance to flow-induced hypertension in the retinal artery and umbilical artery. Tip: hANP may improve PIH and placenta-fetal circulatory function.