药理维持生命所必需的血液携氧能力依赖于肾脏分泌促红细胞素。体内没有促红细胞生成素(EPO)的储存,当缺氧时可刺激EPO的生成,并通过组织的氧分压调节其生成。因此在红细胞生成和EPO的产生之间存在一个反馈调节系统,即肾脏供氧不足促使EPO生成,而红细胞生成增加又将抑制EPO的活性。 Pharmacology The ability of blood to carry oxygen necessary for the maintenance of life depends on the secretion of erythrocyte by the kidneys. There is no storage of erythropoietin (EPO) in the body, which stimulates the production of EPO when hypoxia and regulates its production through the tissue’s partial pressure of oxygen. Therefore, there is a feedback regulation system between erythropoiesis and EPO production. That is, insufficient oxygen supply to the kidney causes EPO production, and the increase of erythropoiesis will inhibit the activity of EPO.