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目的探讨促性腺激素释放激素激动剂 (GnRHa)对子宫肌瘤内雌、孕激素受体 (ER、PR)、表皮生长因子受体 (EGF -R)的影响。 方法测定 1 3例子宫肌瘤患者经GnRHa治疗 3月后肌瘤内雌、孕激素受体和EGF -R水平 ,并以 2 8例未用药肌瘤作对照。 结果GnRHa治疗组肌瘤内ER、PR、EGF -R水平明显低于对照组。 结论GnRHa除减少肌瘤内ER、PR外 ,使肌瘤内EGF -R的水平下降可能是GnRHa治疗子宫肌瘤的一个重要机制
Objective To investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on estrogen and progesterone receptor (ER, PR) and epidermal growth factor receptor (EGFR) in uterine fibroids. Methods The levels of estrogen and progesterone receptor and EGF-R in fibroids of 13 patients with uterine fibroids treated with GnRHa for 3 months were determined. Twenty-eight patients without fibroids were used as controls. Results The levels of ER, PR and EGF-R in myoma of GnRHa group were significantly lower than those in control group. Conclusions GnRHa may reduce the level of EGF-R in fibroids in addition to decreasing ER and PR in fibroids, which may be an important mechanism of GnRHa treatment of uterine fibroids