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目的 评价络泰对激素性股骨头坏死的治疗作用。方法 将 30只兔随机分为空白对照组、模型组、治疗组 ,于实验后 8,16周分别进行血液流变学、血脂测定 ,16周处死动物行组织形态学观察。结果 治疗组动物血浆和全血粘度、红细胞聚集指数、总胆固醇、甘油三酯均明显低于模型组 (P<0 .0 5 ) ,股骨头空骨陷窝数虽没有达到正常水平 ,但较模型组有明显改善 (P<0 .0 5 )。结论 iv经股动脉穿刺介入给予大剂量络泰治疗股骨头坏死 ,可以降低血脂 ,改善血液循环 ,改善股骨头的供血情况 ,从而促进坏死骨修复和新生骨再生。
Objective To evaluate the therapeutic effect of Luotai on steroid-induced femoral head necrosis. Methods Thirty rabbits were randomly divided into blank control group, model group, and treatment group. Hemorheology and blood lipids were measured at 8,16 weeks after the experiment. Animals were sacrificed at 16 weeks for histomorphological observation. Results The plasma and whole blood viscosity, erythrocyte aggregation index, total cholesterol and triglyceride in the treatment group were significantly lower than those in the model group (P<0.05). Although the number of empty vertebral fossa of the femoral head did not reach normal level, There was a significant improvement in the model group (P < 0.05). Conclusion iv Intervention with femoral arterial puncture to treat high-dose Luotai can treat necrosis of the femoral head, which can reduce blood lipids, improve blood circulation, improve the blood supply of the femoral head, and promote necrotic bone repair and regeneration of new bone.