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目的:探讨CD38+细胞在急性髓细胞白血病患者骨髓组织中的表达及其临床意义。方法:应用免疫组织化学染色法,检测急性髓细胞白血病患者初发未治及化疗后完全缓解时骨髓组织中CD38+细胞的表达情况。结果:30例急性髓细胞白血病初发未治组骨髓组织中CD38+细胞阳性表达率明显高于同一患者完全缓解组,两者之间差异具有统计学意义(P<0.05)。结论:CD38+细胞与急性髓细胞白血病的发生、发展及预后存在一定关联。
Objective: To investigate the expression of CD38 + cells in bone marrow of patients with acute myeloid leukemia and its clinical significance. Methods: Immunohistochemical staining was used to detect the expression of CD38 + cells in the bone marrow of patients with acute myeloid leukemia who did not respond to chemotherapy and complete remission after chemotherapy. Results: The positive rate of CD38 + cells in the bone marrow of 30 patients with acute myeloid leukemia was significantly higher than that of the complete remission group. The difference was statistically significant (P <0.05). Conclusion: There is a correlation between CD38 + cells and the occurrence, development and prognosis of acute myeloid leukemia.