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目的:探讨病程5年以下的成年1型糖尿病（T1D）患者微量白蛋白尿的相关因素，为成年T1D患者的糖尿病肾病防治提供依据。方法:研究对象为广东省T1D转化医学研究数据库中2011至2017年入组的病程5年以下的成年T1D患者，对其入组时的横断面资料进行分析。所有患者入组时均记录人口学资料及临床资料，并收集血、尿标本进行血脂、糖化血红蛋白及尿白蛋白/肌酐比值（UACR）的测量，以估算葡萄糖处置率（eGDR）评估胰岛素抵抗程度。根据UACR将患者分为无微量白蛋白尿组（UACR<30 mg/g）和微量白蛋白尿组（UACR≥30 mg/g），采用多重线性回归模型分析成年T1D患者微量白蛋白尿的相关因素。结果:共纳入病程5年以下的T1D患者384例，女197例，占51.3%。患者起病年龄（24.6±12.5）岁，病程2.1（0.6，3.5）年，体质指数（BMI）（19.8±3.2）kg/mn 2，腰臀比0.85±0.21，入组时糖化血红蛋白（9.8±3.3）%。62例患者（16.1%）有微量白蛋白尿。多重线性回归模型分析结果显示，糖化血红蛋白较高，收缩压较高和胰岛素抵抗程度较重是尿微量白蛋白的相关影响因素（n t值分别为2.322、2.868和-2.373，均n P<0.05）。n 结论:短病程的成年T1D患者合并微量白蛋白尿并不罕见，血糖控制差及胰岛素抵抗是微量白蛋白尿的独立相关因素。“,”Objective:To investigate related factors for microalbuminuria in adult type 1 diabetes (T1D) patients of short disease duration (less than 5 years), and provide evidence for prevention of early diabetic kidney disease in this population.Methods:All adult patients enrolled in the Guangdong T1D translational medicine study between 2011 and 2017 with a disease duration of less than 5 years were included in this analysis. At enrollment, patients′ demographic and clinical data were documented, and blood and urine samples were collected for the measurements of blood lipids, glycated hemoglobin A1c and urine albuminuria. Insulin resistance was evaluated by estimated glucose disposal rate (eGDR). Patients were categorized into groups based on urine albumin creatitine ratio (UACR): normoalbuminuric group (UACR<30 mg/g) and microalbuminuric group (UACR≥30 mg/g). Stepwise multivariate linear regression analysis was used to analyze risk factors for microalbuminuria in adult T1D patients of short disease duration.Results:A total of 384 patients were included in this analysis, and 51.3% (197/384) of which was female. The onset age of patients was (24.6±12.5) years, with a disease duration of 2.1(0.6, 3.5) years, body mass index of (19.8±3.2) kg/mn 2, waist hip ratio of 0.85±0.21, and glycated hemoglobin A1c of (9.8±3.3)% at enrollment. Microalbuminuria occurred in 62 patients (16.1%). Multivariate linear analysis showed that higher glycated hemoglobin A1c, higher systolic blood pressure and more severe insulin resistance were related factors for microalbuminuria (n t=2.322, 2.868 and -2.373, respectively, all n P<0.05).n Conclusions:Microalbuminuria was not rare in adult T1D patients of short disease duration. Inadequate glycemic control and insulin resistance were independent related factors for microalbuminuria in this population.