目的:本研究从积极心理学角度出发，探究疾病获益感在鼻咽癌放疗中期患者社会支持与心理痛苦之间的中介作用，为改善鼻咽癌患者心理痛苦水平提供理论依据。方法:便利抽取2018年9月至2019年11月在广西医科大学附属肿瘤医院放疗一区的232例鼻咽癌放疗患者为研究对象，在其放疗中期时采用疾病获益感中文版量表（BFS-C）、心理痛苦温度计（DT）、领悟社会支持量表（PSSS）进行调查，运用SPSS24.0和PROCESS3.3对数据进行统计分析。结果:鼻咽癌患者放疗中期的社会支持在与疾病获益感呈正相关（n r值为0.372，n P<0.001），与心理痛苦存在负相关（n r值为-0.377，n P<0.001），疾病获益感与心理痛苦存在负相关（n r值为-0.736，n P<0.001）；放疗中期的疾病获益感可对社会支持与心理痛苦起着部分中介作用，中介效应占总效应的72.94%。n 结论:鼻咽癌患者放疗中期的社会支持可通过疾病获益感间接影响心理痛苦水平，因此可制定基于该作用的提高疾病获益感的方法来间接改善患者心理痛苦水平，增加心理支持，促进积极的心理适应能力。“,”Objective:This study started from the perspective of positive psychology to explore mediating effect of benefit finding between social support and psychological distress of patients with nasopharyngeal carcinoma during mid-radiotherapy, and provide theoretical reference for improving the psychological distress of them.Methods:Benefit Finding Scale Chinese (BFS-C), Distress Thermometer (DT), Perceived Social Support Scale (PSSS) were applied to 232 patients with nasopharyngeal carcinoma during mid-radiotherapy from a grade-three hospital. The data were statistically analyzed by SPSS 24.0 and PROCESS3.3.Results:Social support of patients with nasopharyngeal carcinoma during mid-radiotherapy was positively related to benefit finding (n r=0.372,n P<0.01) ,and negatively related to psychological distress (n r=-0.377, n P<0.01) .Benefit finding was negatively related to psychological distress (n r=-0.736,n P<0.01) . Benefit finding played a partial mediating role in the relationship between social support and psychological distress, which accounted for 72.94% of the total effect.n Conclusion:Social support can influence psychological distress indirectly by benefit finding in patients with nasopharyngeal carcinoma during mid-radiotherapy, which can be based to design an intervention of benefit finding to improve psychological distress indirectly, augment psychological support and promote positive mental adaptive ability.