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目的观察朝医三神散对血管性痴呆模型大鼠学习记忆的影响,探讨其治疗血管性痴呆的疗效机制。方法采用双侧颈总动脉结扎法制成血管性痴呆大鼠模型,Wistar系雄性大鼠60只,随机分为6组,观察VD模型大鼠学习记忆能力及血清中SOD、MDA、GSH-Px水平的变化,探讨VD的发病机制和三神散对VD模型大鼠缺血脑组织的保护作用。结果三神散高剂量组与模型组相比较,大鼠APLP明显缩短;与模型组比较,三神散高中剂量组血清SOD、GSH-Px活性均明显升高(P<0.05),MDA含量下降(P<0.05)。结论三神散能明显提高痴呆模型大鼠的学习记忆能力,拮抗自由基对脑组织的损伤,提高SOD、GSH-Px的活性,降低MDA的含量,可能有抑制神经细胞凋亡作用,保护神经细胞,促进脑功能的恢复等,从而达到治疗血管性痴呆的目的。
Objective To observe the effect of Chaiyisankisan on learning and memory of vascular dementia model rats and to explore its curative effect on vascular dementia. Methods A rat model of vascular dementia was established by bilateral common carotid artery ligation. Sixty male Wistar rats were randomly divided into 6 groups. The learning and memory abilities and serum levels of SOD, MDA and GSH-Px in VD rats were observed. To investigate the pathogenesis of VD and the protective effects of San She Powder on ischemic brain in VD rats. Results Compared with the model group, the Sanxiao Powder high dose group showed a significant reduction in APLP. Compared with the model group, the activity of SOD and GSH-Px in the Sanxiao Powder high dose group was significantly increased (P <0.05), while the MDA content was decreased (P <0.05). Conclusion SanSan Powder can obviously improve the learning and memory ability of dementia model rats, antagonize the damage of free radicals to brain tissue, increase the activity of SOD and GSH-Px and decrease the content of MDA, which may inhibit the apoptosis of nerve cells and protect the nerve Cells, promote the recovery of brain function, so as to achieve the purpose of treatment of vascular dementia.