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目的研究泌尿生殖道支原体感染患者同时伴其他病原生物的感染状况。方法用病原培养法、抗原或抗体免疫检测法及显微镜观察法,对2003年1~12月在该院门诊以泌尿生殖系统不适就诊患者的泌尿生殖道标本,进行病原生物检测,同时进行有关病原生物的体外药敏试验,并对合并感染情况进行统计分析。结果286例支原体感染患者同时伴有其他病原生物感染者257例(89.9%),其中以21~30岁和31~40岁两年龄组合并感染率最高,分别为50.97%和44.75%。合并感染菌以表皮葡萄球菌最多,为92例(35.80%),其次分别是金黄色葡萄球菌61例(23.74%)、白色念珠菌36例(14.01%)和腐生葡萄球菌31例(12.06%),合并感染的性病病原体较少。多重感染中三重感染35例(13.62%),四重感染10例(3.90%)。药敏试验显示,对支原体耐药的某些常用抗生素如红霉素、四环素、青霉素、氧氟沙星等,对同时合并感染的其他病原微生物也显示了较高的耐药性。结论泌尿生殖系统支原体感染患者合并其他病原生物感染的情况已相当严重,且日趋复杂,常用抗生素耐药也有增多趋势。本研究结果提示,临床应重视对泌尿生殖系统不适患者,特别是支原体感染患者,进行全面系统的病原生物检测和药敏试验,这对预防和有效治疗泌尿生殖系统感染具有十分重要的意义。
Objective To study the infection of mycoplasma genital tract patients with other pathogens. Methods Pathogen culture, antigen or antibody immunoassay and microscopy were used to detect the pathogen in the genitourinary tract of patients with genitourinary discomfort from January to December in 2003. At the same time, Biological susceptibility testing in vitro, and statistical analysis of the combined infection. Results A total of 257 cases (89.9%) of 286 cases with mycoplasma infection were infected with other pathogens. The highest infection rates were 50.97% and 44.75% in both 21-30 years old and 31-40 years old groups. Staphylococcus epidermidis was the most common in the co-infected patients, 92 cases (35.80%) were followed up, followed by 61 cases (23.74%) of Staphylococcus aureus, 36 cases of Candida albicans (14.01%) and 31 cases of Staphylococcus saprophytic (12.06% , With less infection of STD pathogens. In multiple infections, 35 cases (13.62%) were infected by triple infection and 10 cases (3.90%) were infected by quadruple infection. Drug susceptibility tests showed that some commonly used antibiotics resistant to mycoplasma such as erythromycin, tetracycline, penicillin, ofloxacin, etc., also showed high resistance to other pathogenic microorganisms simultaneously infected. Conclusion The cases of genitourinary tract mycoplasma infection combined with other pathogen infections have been quite serious, and have become more and more complicated. There is also an increasing trend of common antibiotic resistance. The results of this study suggest that clinical should pay attention to patients with genitourinary disorders, especially patients with mycoplasma infection, a comprehensive and systematic pathogen detection and drug susceptibility testing, which is very important for the prevention and effective treatment of genitourinary infections.