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目的:评价复方嗜酸乳杆菌配合常规三联疗法治疗胃溃疡患者清除幽门螺杆菌(Hp)对溃疡愈合的影响。方法:选取2013年5月—2015年6月间收治的胃溃疡患者120例,根据治疗方案不同将患者分为观察组(72例)和对照组(48例);对照组患者均给予常规三联疗法(克拉霉素、阿莫西林与雷贝拉唑)治疗,观察组患者在对照组基础上均加用复方嗜酸乳杆菌治疗,比较两组患者治疗后的幽门螺杆菌的清除率、溃疡愈合率和不良反应的发生率。结果:治疗14 d后观察组患者溃疡愈合率、Hp清除率明显高于对照组(P<0.05),不良反应的发生率低于对照组(P<0.05)。结论:复方嗜酸乳杆菌配合常规三联疗法用于治疗胃溃疡患者的溃疡愈合率和Hp清除率优于常规三联疗法,且不良反应的发生率较低。
Objective: To evaluate the effects of compound acidobacillus acidophilus combined with conventional triple therapy in the treatment of gastric ulcer patients with Helicobacter pylori (Hp) on ulcer healing. Methods: One hundred and twenty patients with gastric ulcer were selected from May 2013 to June 2015. The patients were divided into the observation group (72 cases) and the control group (48 cases) according to the different treatment plans. The control group patients were given conventional triad (Clarithromycin, amoxicillin and rabeprazole). The patients in the observation group were treated with compound Lactobacillus acidophilus on the basis of the control group. The clearance rates of Helicobacter pylori, ulcer Healing rate and the incidence of adverse reactions. Results: The healing rate and Hp clearance rate of the observation group were significantly higher than those of the control group (P <0.05) after 14 days of treatment, and the incidence of adverse reactions was lower than that of the control group (P <0.05). Conclusion: The combination of Lactobacillus acidophilus and conventional triple therapy for the treatment of gastric ulcer patients ulcer healing rate and Hp clearance than conventional triple therapy, and the incidence of adverse reactions is low.