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Ａ组轮状病毒的ＶＰ４和ＶＰ７多肽是刺激机体产生中和抗体的主要保护性抗原。我们总结了世界多个地区和国家Ｇ１型轮状病毒流行株ＶＰ４和ＶＰ７基因的分子流行病学调查结果，并根据ＶＰ７多肽序列绘制了分子系统分类树。结果表明，所有流行株ＶＰ４基因的高变区具有相似的氨基酸组成，而ＶＰ７多肽疏水区，特别是已知的抗原决定簇ＶＲ３，ＶＲ４及ＶＲ６的氨基酸组成有规律性变异，提示这些毒株间在抗原性上有微小差异。分子系统分类树将所有毒株分为三个与氨基酸组成相对应的亚组，各个亚组的成员构成反映出了世界范围内轮状病毒流行株的分布具有较明显的地域性。
The VP4 and VP7 polypeptides of Group A rotaviruses are the major protective antigens that stimulate the body to produce neutralizing antibodies. We summarize the molecular epidemiological findings of the VP4 and VP7 genes of the G1 rotavirus strains in many regions and countries in the world and draw a phylogenetic tree based on the VP7 polypeptide sequences. The results showed that the hypervariable regions of VP4 gene of all the strains had similar amino acid composition, while the amino acid composition of the VP7 polypeptide hydrophobic region, especially the known antigenic determinants VR3, VR4 and VR6 showed regular variation, suggesting that these strains There are slight differences in antigenicity. The molecular phylogenetic tree divides all the strains into three subgroups corresponding to the amino acid composition, and the composition of each subgroup reflects that the distribution of the rotavirus strains in the world is more obvious.