近年来,国外对透皮治疗系统(Transdermal Therapeutic System)的研究,进展甚速。因为它有许多优点,如:药物不受胃肠道吸收和肝脏“首过效应”的影响,而且给药方便、无痛苦、吸收率可控制、血药浓度稳定,无口服或注射制剂所固有的峰谷现象等。但由于皮肤的屏障作用,并非所有药物均能透皮给药,因而使透皮治疗系统的临床应用受到限 In recent years, foreign research on transdermal Therapeutic System has progressed rapidly. Because it has many advantages, such as: the drug is not affected by the gastrointestinal tract absorption and the “first pass effect” of the liver, and the administration is convenient and painless; the absorption rate can be controlled; the plasma concentration is stable; The peak and valley phenomenon. However, due to the barrier effect of the skin, not all drugs can be transdermally administered, so that the clinical application of the transdermal therapeutic system is limited