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用2月龄去势雄性SD大鼠28只，建立皮质损伤模型，采用AChE染色法，通过计算切口两侧纤维数观察了睾丸酮对鼠脑皮质胆碱能纤维损伤后再生的影响。结果：损伤1周后用药组的损伤切口吻侧区的纤维密度明显高于损伤1周后的对照组和正常组（P＜0．01）；2周后，用药组纤维密度虽仍高于同期对照组（P＜0．01），但较1周时的密度明显降低；4周后用药组吻侧纤维密度较2周时升高，但与同期对照组差别不明显。同时也看到1周用药组损伤切口尾侧区的纤维密度甚低，明显低于正常值（P＜0．01），与同期报伤对照组差别不明显；2周和4周用药组尾侧区纤维密度增加高于对照组（P＜005）。提示：睾丸酮对鼠脑皮质损伤后胆碱能纤维再生有促进作用。
28 male castrated SD rats aged 2 months were used to establish the model of cortical injury. AChE staining was used to observe the effect of testosterone on the regeneration of cholinergic fibers after cerebral cortex injury. Results: After 1 week of injury, the fiber density in the kisses of the injured area in the wound healing group was significantly higher than that in the control group and the normal group after 1 week of injury (P <0.01). After 2 weeks, the fiber density in the treated group was still higher than Compared with the control group at the same period (P <0.01), the density at 1 week was significantly lower than that at 1 week. After 4 weeks, the density of the kiss side fibers increased, but the difference was not significant compared with the control group. At the same time, we also found that the fiber density in the tail caudal area of the wound healing group was significantly lower than that of the normal group (P <0.01) Side of the fiber density increased higher than the control group (P <005). TIP: Testosterone promotes the regeneration of cholinergic fibers after cerebral cortex injury in rats.