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目的本文探讨倍他乐克临床使用不良反应发生的最小剂量、人群分布及主要类型。方法汇总分析国内外临床、实验报道。结果一般发生不良反应时最小剂量为50mg/d,主要人群分布为年老患者、合并相关疾病、联合用药的患者。主要不良反应有过敏反应、低血压、窦性心动过缓、气道阻力增加、新发糖尿病危险、性功能障碍、睡眠障碍。结论目前在国内基层医院倍他乐克已成为β受体阻滞剂代表药物,已成为心血管专科医师常用处方药物。随着使用剂量增加至大于50mg/d及联合用药、长期使用或突然停药不良反应发生增加。临床使用中必须全面了解并掌握它的药理作用及临床适应证、不良反应。
Objective This article explores the minimum dose, population distribution, and major types of metoprolol in clinical adverse drug reactions. Methods A summary of clinical and experimental reports at home and abroad. Results Generally, the minimum dose was 50mg / d with adverse reactions. The main population was aged patients with associated diseases and combination therapy. The main adverse reactions are allergic reactions, hypotension, sinus bradycardia, increased airway resistance, new onset of diabetes, sexual dysfunction, sleep disorders. Conclusion At present, Betaloc in Chinese primary hospitals has become the representative drug of beta blockers and has become a commonly used prescription drug by cardiovascular specialists. As the dosage is increased to more than 50mg / d and combination, long-term use or sudden withdrawal adverse reactions increase. Clinical use must fully understand and grasp its pharmacological effects and clinical indications, adverse reactions.