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目的观察消癜汤治疗儿童过敏性紫癜(HSP)的疗效及对其肠道菌群的影响。方法 65例HSP患儿,试验组38例和对照组27例,对照组予西医常规治疗[口服氯雷他定片,体重<30kg者每次5mg,体重≥30kg者每次10mg,每日1次;关节、消化道症状严重者予静滴甲强龙琥珀酸钠,1~2mg/(kg·d),给药疗程<1周],试验组在西医常规治疗基础上给予消癜汤,每日1剂。治疗2周后观察两组患儿临床疗效、临床症状改善及粪便标本中乳酸杆菌、双歧杆菌和大肠杆菌的含量变化。结果试验组临床疗效总有效率为92.11%,高于对照组的81.48%(P<0.05)。在缓解腹痛的时间、改善尿隐血方面试验组优于对照组(P<0.05)。试验组治疗后乳酸杆菌含量较治疗前显著增加,且乳酸杆菌含量显著高于对照组(P<0.05)。结论消癜汤治疗儿童HSP疗效确切,其作用机制可能与调节肠道乳酸杆菌含量有关。
Objective To observe the therapeutic effect of Hexile Decoction on children with Henoch-Schonlein Purpura (HSP) and its influence on intestinal microflora. Methods 65 cases of HSP children, 38 cases in the experimental group and 27 cases in the control group, the control group to conventional Western medicine [oral loratadine tablets, body weight <30kg each 5mg, body weight ≥ 30kg each 10mg, day 1 The patients in severe joint and gastrointestinal symptoms were treated with intravenous methylprednisolone sodium succinate (1 ~ 2mg / (kg · d)) for 1 week. The experimental group was given Qidan Tang on the basis of routine treatment of Western medicine, 1 dose daily After 2 weeks of treatment, the clinical curative effect, improvement of clinical symptoms and changes of content of Lactobacillus, Bifidobacterium and Escherichia coli in the stool samples were observed. Results The total effective rate of the experimental group was 92.11%, higher than that of the control group (81.48%, P <0.05). The experimental group was better than the control group in relieving the time of abdominal pain and improving the occult urine (P <0.05). The content of Lactobacillus in the experimental group after treatment was significantly higher than that before treatment, and the content of Lactobacillus was significantly higher than that of the control group (P <0.05). Conclusion The therapeutic effect of Qidian Decoction on children with HSP is exact and its mechanism may be related to the regulation of intestinal Lactobacillus.