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11β-羟基类固醇脱氢酶(11β-HSD)是糖皮质激素的代谢酶,该酶分为11β-HSD1与11β-HSD2两种亚型。11β-HSD1使无活性的可的松转化为有活性的氢化可的松,参与了肥胖、高血脂、高血糖、高血压等代谢综合征的病理生理过程。另外,高水平的糖皮质激素暴露与神经系统功能紊乱及年龄相关性认知功能障碍有关。11β-HSD2通过使糖皮质激素失活起到保护盐皮质激素受体的作用。反之,11β-HSD2基因缺陷或突变会导致高盐皮质激素综合征,表现为水钠潴留、高血压、低血钾。通过对11β-HSD的功能及其作用机制的深入研究,为代谢综合征及其相关疾病提供了新的治疗方法。
11β-Hydroxysteroid dehydrogenase (11β-HSD) is a glucocorticoid metabolic enzyme that is divided into 11β-HSD1 and 11β-HSD2 subtypes. 11β-HSD1 converts inactive cortisone to active hydrocortisone, participating in the pathophysiological processes of metabolic syndromes such as obesity, hyperlipidemia, hyperglycemia and hypertension. In addition, high levels of glucocorticoid exposure are associated with neurological dysfunction and age-related cognitive impairment. 11 [beta] -HSD2 acts to protect the mineralocorticoid receptor by inactivating the glucocorticoid. Conversely, 11β-HSD2 gene defects or mutations will lead to high mineralocorticoid syndrome, manifested as Shuinazhuliu, hypertension, hypokalemia. By studying the function of 11β-HSD and its mechanism of action, we provide a new therapeutic method for metabolic syndrome and its related diseases.