神经外科患者大多数病情危重急,常伴有不同程度的意识障碍、肢体功能障碍、语言障碍等,临床上常需尽快应用脱水剂降低颅内压。最常应用的方法是快速静脉输注20%甘露醇,通常为6h或8h快速静脉滴注1次。频繁静脉穿刺可损伤静脉;甘露醇注射液是六碳多元醇,为高渗透压性脱水剂,20%甘露醇在临床广泛应用,特别是神经外科疾病治疗中尤为重要~([1])。但频繁应用或用量过大,发生不良反应的概率就会大 Most patients with neurosurgical emergency critical illness, often accompanied by varying degrees of disturbance of consciousness, limb dysfunction, language barriers, etc., often need to apply dehydration agents clinical as soon as possible to reduce intracranial pressure. The most commonly used method is rapid intravenous infusion of 20% mannitol, usually 6h or 8h rapid intravenous infusion 1. Frequent venipuncture can damage the vein; mannitol injection is a six-carbon polyol, hypertonic pressure dehydrating agent, 20% mannitol is widely used in clinical practice, especially neurosurgical disease treatment is particularly important ~ ([1]). However, frequent applications or excessive dosage, the probability of adverse reactions will be large