目的:探究宫颈病变中CD147、MMP-3及TIMP-9表达及临床意义。方法:选取宫颈病变样本110例,宫颈上皮病变(CIN)72例,其中CINⅠ16例,CINⅡ21例,CINⅢ35例,宫颈浸润癌38例。采用免疫组化法检测各组样本切片中CD147、MMP-3及TIMP-9的表达量。结果:宫颈癌组CD147 MOD值均明显高于CINⅠ、Ⅱ组和CINⅢ组(P<0.05);宫颈癌样本MMP-3、TIMP-9蛋白含量MOD值与MMP-3/TIMP-9比值均高于另外两组宫颈病变样本(P<0.05);但CINⅢ组与CINⅠ、Ⅱ组二者相比,差异无统计学意义(P>0.05)。结论:CD147蛋白对早期宫颈病变预测、诊断及治疗预后的判断具有重要意义;在宫颈浸润性癌病例中,MMP-3、TIMP-9等生物学指标可能对宫颈病变有效预测。 Objective: To investigate the expression of CD147, MMP-3 and TIMP-9 in cervical lesions and its clinical significance. Methods: 110 cases of cervical lesions and 72 cases of cervical epithelial lesions (CIN) were selected, of which 16 cases were CINⅠ, 21 cases were CINⅡ, 35 cases were CINⅢ and 38 cases were cervical invasive carcinoma. Immunohistochemistry was used to detect the expression of CD147, MMP-3 and TIMP-9 in each group of samples. Results: The CD147 MOD values ​​in cervical cancer group were significantly higher than those in CINⅠ, Ⅱ group and CINⅢ group (P <0.05). The values ​​of MOD values ​​of MMP-3 and TIMP-9 in cervical cancer samples were higher than MMP-3 / TIMP-9 In the other two groups of cervical lesions (P <0.05), there was no significant difference between CIN Ⅲ group and CIN Ⅰ and Ⅱ groups (P> 0.05). Conclusion: CD147 protein is of great significance in the prediction, diagnosis and prognosis of early cervical lesions. Biological indicators such as MMP-3 and TIMP-9 may be effective predictors of cervical lesions in invasive cervical cancer.