原位肝移植(OLT)后癫痫发生率为4%~42%,大多数发生在肝移植后第1个月内,最常见的病因是免疫抑制剂毒性或伴随濒死事件。除更改免疫抑制治疗方案等去除病因治疗外,常用抗癫痫药物短程治疗。免疫抑制剂由肝脏代谢,苯妥英等抗癫痫药物诱导肝细胞色素P450系统,因此OLT后维持适当的 The incidence of epilepsy after orthotopic liver transplantation (OLT) is 4% -42%, most of which occur within the first month after liver transplantation. The most common causes are immunosuppressive toxicities or accompanying dying events. In addition to changing immunosuppressive treatment programs to remove the cause of treatment, the commonly used short-term treatment of antiepileptic drugs. Immunosuppressive agents are metabolized by the liver, and phenytoin and other antiepileptic drugs induce the hepatocyte cytochrome P450 system, thus maintaining appropriate after OLT