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目的 探讨老年妇女外阴癌组织中p5 3表达及人乳头瘤病毒 (HPV)感染与外阴癌发生及临床发展的关系。 方法 应用免疫组化法检测老年妇女外阴鳞状细胞癌 (外阴癌 ) 6 8例及老年妇女外阴营养不良 38例病例蜡块包埋组织中p5 3、HPV的表达情况 ,并选用 15例外阴正常皮肤作为对照。 结果 p5 3、HPV在老年妇女外阴癌组织中阳性表达率分别为 5 4 4%、45 6 % ,老年妇女外阴营养不良组织中为 18 4%、5 5 3% ,老年妇女正常外阴皮肤无阳性表达。外阴癌与外阴营养不良、正常对照比较差异有显著性 (分别为P <0 0 5及P <0 0 1)。 结论 老年妇女外阴癌组织中p5 3、HPV阳性表达率较高。p5 3突变在老年妇女外阴癌的发生过程中起重要作用 ,高危型HPV的感染促进外阴癌的发生
Objective To investigate the expression of p5 3 and the relationship between human papillomavirus (HPV) infection and the occurrence and clinical development of vulvar cancer in vulvar cancer tissues of elderly women. Methods Immunohistochemistry was used to detect the expression of p53 and HPV in 68 cases of vulva squamous cell carcinoma (vulvar cancer) and 38 cases of vulvar dystrophy in elderly women. Fifteen cases of normal vulva Skin as a control. Results The positive expression rates of HPV in vulvar cancer tissues of elderly women were 54.4% and 45.6%, respectively, 18.4% and 55.3% of the vulvar dystrophies in the elderly women, respectively, and no positive in the vulva skin of the elderly women expression. Vulvar carcinoma and vulvar dystrophy, the normal control was significantly different (P <0 05 and P 0 01, respectively). Conclusion The positive rate of p5 3 and HPV in the vulva cancer tissues of older women is higher. The mutation of p5 3 plays an important role in the occurrence of vulvar cancer in elderly women. The infection of high-risk HPV promotes the development of vulvar cancer