广谱抗菌素被广泛用于感染疾病后,各种耐药菌株逐年增多,细菌对抗菌素的耐药性相应增加;外源性厌氧菌感染减少后,内源性厌氧菌的临床感染率增多;继发性深部真菌感染的发病率在长期使用广谱抗菌素后有所增加。针对这些临床上迫切需要解决的问题,人们从合成新药与开拓老药新用途等方面进行了“对症找药”的研究与开发, Broad spectrum antibiotics are widely used in infectious diseases, a variety of drug-resistant strains increased year by year, the antibacterial resistance of bacteria increased accordingly; reduction of exogenous anaerobic infections, the clinical infection rate of endogenous anaerobic bacteria increased ; The incidence of secondary deep fungal infections increased after long-term use of broad-spectrum antibiotics. In view of these urgent problems that need to be solved clinically, people from the aspects of synthesizing new drugs and exploring new uses of old drugs have carried out research and development of “symptomatic looking for medicine”