论文部分内容阅读
目的 了解南京地区TTV病毒感染情况 ,重叠TTV感染对慢性乙型肝炎病变程度和HBV复制的影响。方法 采用巢式PCR方法检测血清标本中TTV -DNA。结果 469份血清标本中 ,TTVDNA总检出率为 2 1 1% ( 99/469)。其中健康人群、献血员、血透患者、甲型肝炎、乙型肝炎、丙型肝炎、戊型肝炎、庚型肝炎、非甲 -非庚型肝炎检出率分别是9 4%、3 3 3 %、3 0 8%、11 6%、19 9%、15 4%、8 7%、9 5 %、3 4 1% ;有 2 8例慢性乙型肝炎合并TTV感染 ,轻度、中度和重度慢性乙型患者中TTV检出率无显著差异 ,TTV阳性组和阴性组之间肝功能改变相近。HBeAg、HBVDNA阳性组和HBeAg、HBVDNA阴性组TTVDNA检出率相当。结论 南京地区存在TTV感染 ,TTV是导致非甲 -非庚型肝炎的重要原因 ,TTV可能存在非血源性传播途径 ;慢性乙型肝炎重叠TTV感染对病变程度和HBV复制无明显影响
Objective To investigate the influence of TTV infection and overlap TTV infection on the degree of chronic hepatitis B and HBV replication in Nanjing. Methods Nested PCR was used to detect TTV-DNA in serum samples. Results The total positive rate of TTVDNA in 469 serum samples was 21.1% (99/469). Among them, the detection rates of healthy people, blood donors, hemodialysis patients, hepatitis A, hepatitis B, hepatitis C, hepatitis E, hepatitis G, non-hepatitis A and non-hepatitis G were respectively 9 4%, 3 3 3 28%, 11 6%, 19 9%, 15 4%, 87%, 95%, 34 1% respectively; there were 28 cases of chronic hepatitis B with TTV infection, mild and moderate There was no significant difference in the detection rate of TTV among severe chronic B patients, and the changes of liver function between TTV positive group and negative group were similar. The detection rates of TTVDNA in HBeAg and HBVDNA positive group and in HBeAg and HBVDNA negative group were the same. Conclusions TTV infection exists in Nanjing. TTV is an important cause of non-A-HepG. TTV may have non-blood-borne pathways. Chronic hepatitis B overlap TTV infection has no effect on pathological changes and HBV replication