论文部分内容阅读
【目的】比较盆腔外照射、高剂量率后装联合5-氟尿嘧啶(5-fluorouracil,5-FU)、顺铂(Cisplatin,DDP)月疗或DDP周疗治疗IIB—IVA期宫颈癌的近期疗效及不良反应,探讨治疗晚期无远处转移宫颈癌的优化方案。【方法】80例符合纳入标准的宫颈癌患者被随机分为A、B组,每组40例。两组患者均行DT 30 Gy全盆腔野照射,随后中央挡铅板照射,DT 20 Gy。腔内照射A点总剂量42 Gy。A组给予5-FU 1 000 mg/m2/day,DDP 20 mg/m2/day,静滴5 d,28 d为1疗程,共3疗程。B组每周给予DDP 30 mg/m2静滴,共6疗程。观察两组肿瘤消退、并发症及治疗依从性。【结果】B组完成化疗及放疗人数均显著大于A组(P<0.05)。完成放化疗剂量≥80%的人数显著大于A组(P<0.05)。A组III度以上骨髓抑制及III级以上恶心呕吐反应率显著大于B组(P<0.05)。治疗后3个月两组患者完全缓解率无统计学差异(P>0.05)。【结论】两组方案治疗晚期无远处转移宫颈癌的疗效相似,但DDP周疗毒性反应低,依从性好,可行性强。
【Objective】 To compare the short-term effects of extra-pelvic irradiation and high-dose rate post-loading combined with 5-fluorouracil (5-FU), cisplatin (DDP) or DDP in the treatment of stage IIB-IVA cervical cancer And adverse reactions, to explore the treatment of advanced non-distant metastasis of cervical cancer optimization program. 【Methods】 Eighty patients with cervical cancer who met the inclusion criteria were randomly divided into A and B groups, 40 cases in each group. Two groups of patients underwent DT 30 Gy whole pelvic field irradiation, followed by the central block lead exposure, DT 20 Gy. The total dose of point A was 42 Gy. A group given 5-FU 1 000 mg / m2 / day, DDP 20 mg / m2 / day, intravenous infusion of 5 d, 28 d for a course of treatment, a total of 3 courses. Group B received weekly DDP 30 mg / m2 intravenous infusion, a total of 6 courses. Two groups of tumor regression, complications and treatment compliance were observed. 【Results】 The number of patients receiving chemotherapy and radiotherapy in group B were significantly greater than those in group A (P <0.05). The number of people who completed radiotherapy and chemotherapy more than 80% was significantly greater than that of group A (P <0.05). In group A, the myelosuppression of grade III or higher and the grade III or higher nausea and vomiting were significantly higher than those in group B (P <0.05). There was no significant difference in complete remission rate between the two groups after 3 months of treatment (P> 0.05). 【Conclusions】 The curative effect of the two groups in the treatment of advanced cervical cancer without distant metastasis is similar, but the toxicity of DDP is low, the compliance is good and the feasibility is good.