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杂环化合物广泛存在于天然产物和药物分子中,具有良好的生物活性和药物活性.硝基烯烃是杂环合成中的重要合成中间体,可以用于构建含C-O键,C-N键和C-S键的杂环类化合物,从而能够简洁快速地实现重要杂环化合物的合成,尤其在构建吡咯环、哌啶环和吡啶环具有重要意义.在杂环合成中硝基烯烃主要通过Michael加成、Diels–Alder关环、1,3-偶极和环加成、Morita–Baylis–Hillman反应及串联反应等实现杂环化合物的合成.本文对硝基烯烃在杂环合成中近10年的发展和应用进行综述.
Heterocyclic compounds widely exist in natural products and drug molecules, and have good biological activities and drug activity.Nitroalkenes are important synthetic intermediates in heterocyclic synthesis, which can be used to construct CO bonds, CN bonds and CS bonds Heterocyclic compounds, which can be concise and rapid synthesis of important heterocyclic compounds, especially in the construction of pyrrole ring, piperidine ring and pyridine ring is of great importance in the heterocyclic synthesis of nitroolefins by Michael addition, Diels- Alder ring closure, 1,3-dipolar and cycloaddition, Morita-Baylis-Hillman reaction and tandem reaction etc. In this paper, the development and application of nitroalkenes in heterocyclic synthesis for nearly 10 years Summary.