目的:观察米索前列醇在无痛人工流产中的应用效果。方法:选择我科收治的78例行无痛人工流产术的健康孕妇,随机分为3组,即:术前1h口服米索前列醇组(简称1组)、术前1h直肠内放置米索前列醇组(简称2组),以及术前未用药组(简称3组),每组各26例。观察三组患者的宫颈软化情况,以及比较宫缩幅度、术中出血量、手术时间手术相关指标。结果:与3组比较,1组与2组的宫颈软化有效率均升高明显,差异具显著统计学意义(P<0.01);与1组比较,2组的宫颈软化有效率升高明显,差异具统计学意义(P<0.05)。与3组比较,1组与2组的宫缩幅度增加明显,术中出血量与手术时间则降低明显,差异均具统计学意义(P<0.05)。1组与2组比较,差异未见统计学意义(P>0.05)。结论:口服或直肠内放置米索前列醇,均可有效软化无痛人工流产术患者宫颈,促进子宫收缩,降低术中出血量,缩短手术时间,具有临床推广价值。 Objective: To observe the effect of misoprostol in painless induced abortion. Methods: A total of 78 healthy pregnant women undergoing painless abortion were enrolled in our study. They were randomly divided into 3 groups: 1h oral preoperative misoprostol group (referred to as 1 group), 1h preoperative placement of misoprostol PRA group (referred to as 2 groups), and preoperative non-medication group (referred to as 3 groups), each group of 26 cases. To observe the three groups of patients with cervical softening, as well as to compare the magnitude of contractions, intraoperative blood loss, surgical time related indicators of surgery. Results: Compared with the three groups, the effective rates of cervix softening in groups 1 and 2 both increased significantly (P <0.01). Compared with group 1, the cervical softening efficiency increased obviously in group 1 and group 2, The difference was statistically significant (P <0.05). Compared with the three groups, the contractions amplitude increased obviously in Group 1 and Group 2, and the blood loss and operation time decreased significantly (P <0.05). 1 group and 2 groups, the difference was not statistically significant (P> 0.05). Conclusion: Oral or rectal placement of misoprostol can effectively soften painless artificial abortion in patients with cervical, promote uterine contraction, reduce intraoperative bleeding, shorten the operation time, with clinical value.