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目的:观察急性冠状动脉综合征(ACS)中B型脑钠肽(BNP)与血小板平均体积(MPV)的关系,并探讨二者与冠状动脉支架置入术(PCI)中TIMI血流的关系。方法:入选诊断为ACS患者156例[ST段抬高性急性心肌梗死(STEMI)52例,非ST段抬高性心肌梗死(NSTEMI)41例,不稳定型心绞痛(UAP)63例],对照组(非冠心病)60例,测量血小板计数(PLC),MPV,BNP,超敏C反应蛋白(hsCRP)数值,并观察分析和MPV与STEMI患者PCI中TIMI血流的关系。结果:同对照组相比ACS组中BNP明显升高[STEMI(267.4±51.3)ng/L,NSTEMI(245.7±46.2)ng/L,UAP(172.2士32.5)ng/L,对照组(46.6士10.7)ng/L];hsCRP明显升高[STEMI(12.5±2.3)mg/L,NSTEMI(13.8±3.7)mg/L,UAP(10.9±2.4)mg/L,对照组(5.1士1.2)mg/L];MPV明显升高[STEMI(10.6±0.22)fl,NSTEMI(12.8±0.19)fl,UAP(11.6±0.27)fl,对照组(9.1±0.18)fl];多元相关分析提示BNP与MPV正相关(r=0.294),hsCRP同MPV正相关(r=0.483),在52例STEMI行PCI患者BNP及MPV与TIMI血流呈负相关。结论:ACS中BNP与MPV明显升高,二者呈正相关;在STEMI中BNP及MPV与PCI中TIMI血流水平分级呈负相关。
OBJECTIVE: To observe the relationship between BNP and MPV in patients with acute coronary syndrome (ACS) and to explore the relationship between them and the TIMI flow in coronary stenting . METHODS: Fifty-six patients with ST-segment elevation acute myocardial infarction (STEMI), 41 with non-ST-segment elevation myocardial infarction (NSTEMI) and 63 with unstable angina (UAP) were enrolled in this study. Sixty patients with non-coronary heart disease (CHD) were enrolled in this study. The platelet count (PLC), MPV, BNP and hsCRP were measured. The relationship between MPI and TIMI flow in patients with STEMI was analyzed. Results: Compared with the control group, BNP was significantly increased in ACS group [STEMI (267.4 ± 51.3) ng / L, NSTEMI (245.7 ± 46.2) ng / L, UAP (5.1 ± 1.2) mg / L, NAPI (13.8 ± 3.7) mg / L, UAP (10.9 ± 2.4) mg / L and control group / L]; MPV was significantly higher in STEMI (10.6 ± 0.22) fl, NSTEMI (12.8 ± 0.19) fl, UAP (11.6 ± 0.27) fl, and control group There was a positive correlation between hsCRP and MPV (r = 0.483). There was a negative correlation between BNP, MPV and TIMI blood flow in 52 STEMI patients. Conclusions: BNP and MPV were significantly increased in ACS patients, which were positively correlated with each other. There was a negative correlation between BNP and MPV in STEMI and TIMI grade in PCI.