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目的探讨右美托咪定复合丙泊酚麻醉在保留自主呼吸气管插管中的应用效果。方法将保留自主呼吸行气管插管的手术患者70例随机分为研究组和对照组各35例。研究组在诱导始时予右美托咪定1.0μg/kg静脉输注10min,在输注右美托咪定后5min给予丙泊酚1.5mg/kg静脉注射,10min后行气管插管;对照组给予丙泊酚1.5mg/kg静脉注射,10min后行气管插管。比较2组患者在不同时间点(诱导前、气管插管前、插管时、插管后5min)的心率(HR)与平均动脉压(MAP)水平。结果气管插管前2组HR水平与诱导前相比明显降低,差异有统计学意义(P<0.05);插管时对照组HR、MAP水平与插管前相比显著升高,且研究组显著低于对照组,差异均有统计学意义(P<0.05)。结论右美托咪定复合丙泊酚麻醉应用于保留自主呼吸气管插管手术效果较满意,在诱导插管过程中无呼吸抑制现象及明显不良反应,血流动力学稳定,具有重要的临床应用价值。
Objective To investigate the effect of dexmedetomidine combined with propofol anesthesia in preserving spontaneous respiratory tracheal intubation. Methods Seventy patients undergoing spontaneous breathing and tracheal intubation were randomly divided into study group (35 cases) and control group (35 cases). At the beginning of induction, the study group received intravenous infusion of 1.0 μg / kg dexmedetomidine for 10 min and propofol 1.5 mg / kg intravenously 5 min after infusion of dexmedetomidine. Tracheal intubation was performed 10 min later. Group given propofol 1.5mg / kg intravenously, 10min after tracheal intubation. The heart rate (HR) and mean arterial pressure (MAP) were compared between the two groups at different time points (before induction, before intubation, during intubation, 5 minutes after intubation). Results The levels of HR in the two groups before tracheal intubation were significantly lower than those before intubation (P <0.05). The levels of HR and MAP in control group were significantly higher than those before intubation Significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion Dexmedetomidine combined with propofol anesthesia is more satisfactory for the patients with spontaneous respiration tracheal intubation. There is no respiratory depression and adverse reactions during the induction of intubation, and hemodynamics is stable. It has important clinical application value.