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目的探讨高效液相色谱法(HPLC)同时对利胆排石片中4种蒽醌类成分含量测定情况。方法指定具有丰富经验及专业知识的实验室检验人员完成各批次利胆排石片中4种蒽醌类成分含量检测工作,将所得数据经专业分析后获得结论。结果各批次利胆排石片中大黄酸、大黄酚、大黄素、大黄素甲醚等4种蒽醌类成分含量经HPLC测定后对比,差异无统计学意义(P>0.05)。结论利胆排石片经HPLC可同时对其4种蒽醌类成分含量进行准确测定,有利于提高药品质量控制效果,保障患者疗效及预后。
Objective To investigate the simultaneous determination of four anthraquinones in Laxian Pai tablet by high performance liquid chromatography (HPLC). Methods Lab technicians with rich experience and professional knowledge were appointed to test the contents of four anthraquinones in Lixia Paihuan tablets. The data obtained after professional analysis were concluded. Results The contents of four anthraquinones such as rhein, chrysophanol, emodin and physcion were determined by HPLC. The differences were not statistically significant (P> 0.05). Conclusion The determination of four anthraquinone components by HPLC can simultaneously determine the contents of four anthraquinones, which is beneficial to improve the quality control of drugs and ensure the efficacy and prognosis of patients.