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目的了解腹泻婴幼儿粪便中轮状病毒和腺病毒抗原的感染情况,为临床诊断、治疗提供可靠依据。方法采用胶体金免疫层析法,对2013年1月-2014年12月来本院儿科门诊就诊和住院的3 488例5岁以下腹泻婴幼儿粪便标本,进行轮状病毒和腺病毒抗原检测。结果 3 488例标本中单纯轮状病毒阳性766例(21.96%);单纯腺病毒阳性213例(6.11%),两者差异具有统计学意义(P<0.01)。秋、冬季是轮状病毒好发季节,腺病毒感染呈四季散发。腺病毒在>3岁年龄组中构成比为9.39%,明显低于其他各年龄组(P<0.01)。双重病毒感染37例,阳性检出率为1.06%。结论轮状病毒是引起本院婴幼儿腹泻的主要致病原,双重病毒感染机率较小,及时检测为临床采取正确治疗和隔离措施有重要意义。
Objective To understand the infection of rotavirus and adenovirus antigen in diarrhea infants and young children and provide a reliable basis for clinical diagnosis and treatment. Methods The colony gold immunochromatography assay was used to detect the rotavirus and adenovirus antigen in 3 488 cases of diarrhea infants and young children aged below 5 from the Pediatric Clinic from January 2013 to December 2014 in our hospital. Results Among 3 488 specimens, 766 were positive for rotavirus alone (21.96%), 213 were for adenovirus alone (6.11%), the difference was statistically significant (P <0.01). Autumn and winter rotavirus season, adenovirus infection was distributed in four seasons. The ratio of adenovirus in the group of> 3 years old was 9.39%, which was significantly lower than that of other age groups (P <0.01). 37 cases of double virus infection, the positive detection rate was 1.06%. Conclusions Rotavirus is the main causative agent of diarrhea in infants and young children in our hospital. The chances of double virus infection are small. It is of great significance to take timely measures to correct the treatment and isolation in clinic.