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目的:探讨幽门螺杆菌(Hp)感染与急性心肌梗死(AMI)患者血清炎症反应的关系,为临床防治AMI提供参考。方法:选取2013年4月-2014年11月我院收治的74例AMI患者作为研究组,另选取同期在我院进行体检的74例健康人作为对照组。采用酶联免疫法检测和比较两组患者Hp免疫球蛋白G(Immunoglobulin G,IgG)浓度及血清IL-6、IL-8、IL-18、TNF-α和hs-CRP水平,分析Hp IgG阳性与血清炎症因子水平的相关性。结果:研究组患者的Hp IgG浓度为(60.92±45.15)KU/L,相比于对照组的(32.36±24.08)KU/L明显偏高(P<0.05),且其阳性率为72.97%,明显高于对照组的51.35%(P<0.05);Hp阳性患者IL-6、IL-8、IL-18、TNF-α、hs-CRP明显高于Hp阴性患者的(P<0.05)。Pearson相关分析显示Hp IgG浓度与血清IL-6、IL-8、IL-18、TNF-α、hs-CRP水平均呈显著正相关,相关系数分别为0.735、0.644、0.798、0.674、0.616(P<0.05)。结论:Hp感染与AMI患者血清炎症反应之间存在着密切的关系。
Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and serum inflammatory response in patients with acute myocardial infarction (AMI) and provide a reference for clinical prevention and treatment of AMI. Methods: A total of 74 AMI patients admitted to our hospital from April 2013 to November 2014 were selected as the study group. Another 74 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. The levels of Hp immunoglobulin G (IgG) and the levels of IL-6, IL-8, IL-18, TNF-α and hs-CRP in the two groups were detected by enzyme-linked immunosorbent assay And serum levels of inflammatory cytokines. Results: The Hp IgG concentration in the study group was (60.92 ± 45.15) KU / L, which was significantly higher than that in the control group (32.36 ± 24.08) KU / L (P <0.05), and the positive rate was 72.97% (P <0.05). The levels of IL-6, IL-8, IL-18, TNF-α and hs-CRP in Hp positive patients were significantly higher than those in Hp negative patients (P <0.05). Pearson correlation analysis showed that there was a significant positive correlation between the concentration of Hp IgG and serum IL-6, IL-8, IL-18, TNF-α and hs-CRP levels and the correlation coefficients were 0.735,0.644,0.798,0.674,0.616 (P <0.05). Conclusion: There is a close relationship between Hp infection and serum inflammatory response in AMI patients.