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目的 探讨变应原血清免疫球蛋白E(immunoglobulin E,IgE)检测对飞行人员变应性鼻炎(allergic rhinitis,AR)的临床意义. 方法 抽取拟临床诊断为AR的128例飞行人员静脉血2 ml,采用变应原IgE抗体检测试剂盒测定血清总IgE(total IgE,tIgE)及14种变应原特异性IgE(specific IgE,sIgE),包括7种吸入性变应原和7种食入性变应原.比较AR飞行人员吸入性变应原和食入性变应原强阳性反应率的差异,分析血清tIgE值与变应原sIgE阳性反应率的相关性. 结果 128例AR飞行人员血清tIgE阳性反应率为85.9％(110/128),sIgE的阳性反应率为91.4％(117/128).吸入性变应原阳性反应率前3位为屋尘螨/粉尘螨(66.4％)、树组合(柏树/榆树/梧桐/柳树/杨树)(32.8％)、屋尘(23.4％);食入性变应原阳性反应率前3位为水果组合(芒果/菠萝/苹果/桃子/草莓)(18.0％)、海鲜组合(虾/蟹/扇贝)(16.4％)、鱼类组合(鳕鱼/鲑鱼/鲈鱼)(13.3％);二者同时阳性反应率为12.5％(16/128).吸入性变应原以强阳性反应为主,食入性变应原以弱阳性反应为主,两者强阳性反应率差异有统计学意义(x2=16.881,P＜0.05).变应原血清sIgE阳性反应率与tIgE值呈正相关(r=0.517,P＜0.01). 结论 变应原血清IgE检测判读客观、准确、无创,且不受年龄、疾病、药物、操作等外界条件限制.检测结果可以(半)定量分级显示并可同时测定tIgE水平,在提高飞行人员AR患者的诊断、治疗和预防水平等方面具有重要的临床意义.“,”Objective To study the clinic significance of allergen serum immunoglobulin E (IgE) detection for the flying personnel with allergic rhinitis.Methods One hundred and twentyeight flying personnel with clinically suspected allergic rhinitis were drawn 2 ml venous blood.Serum tIgE (total IgE) and 14 allergen sIgE (specific IgE) including 7 aspiration allergens and 7 food allergens were detected with antibody kit.Strong positive reaction rates of the flying personnel with aspiration allergens and food allergens were compared as well as the correlation of serum tIgE and positive reaction rate of allergen sIgE was analyzed.Results Positive reaction rate of tIgE in 128 flying personnel with allergic rhinitis was 85.9 ％ (110/128) and positive reaction rate of sIgE was 91.4％ (117/128).The top 3 positive reaction rates of aspiration allergens were dust mite (66.4％),tree combination (32.8％) and house dust (23.4％).The top 3 positive reaction rates of food allergens were fruit combination (mango/pineapple/apple/peach/strawberry) (18.0％),seafood combination (shrimp/crab/scallop) (16.4％) and fish combination (ling/trout/weever) (13.3％).Positive response rate of the flying personnel with both aspiration and food allergens was 12.5 ％ (16/128).The aspiration allergens mainly reflected as strong positive reaction while the food allergens mainly expressed as weakly positive reaction.The strong positive reaction showed significance between aspiration and food allergens.(x2=16.881,P＜0.05).The strong positive reaction of allergen serum had the positive correlation to tIgE value (r=0.517,P＜0.01).Conclusions The allergen serum IgE detection have shown its objective,accurate and noninvasive advantages and are with less age,disease,medication,manipulation and other external limitations.The test results can be quantitatively or semi-quantitatively expressed and can determine tIgE level within the detection.So it has certain clinical significance on diagnosis,treatment,evaluation and prevention for the flying personnel with allergic rhinitis.