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用81只雄性大白鼠共分9组,将LRH—A3分为0.02μg、2μg及200μg三种剂量,分别注射2天、20天及60天。在组织学上见200μg注射20天后,睾丸开始出现抑制退化现象。200μg注射60天后,则抑制現象更加明显。睾丸重量下降,曲细精管萎缩,生精细胞疏松脱落,精子细胞溶解,精母细胞膨大变形,形成严重生精障碍。在组织化学上LRH—A_3用200μg注射60天后,可见LDH,
Eighty-one male rats were divided into 9 groups and LRH-A3 was divided into three doses of 0.02 μg, 2 μg and 200 μg, which were injected for 2 days, 20 days and 60 days, respectively. Histologically, after 20 days of 200 μg injection, the testis began to show signs of degeneration. After 200 μg injection for 60 days, the inhibition was more pronounced. The testicular weight decreased, the seminiferous tubules atrophied, the spermatogenic cells loosened and detached, the sperm cells dissolved, and the spermatocytes expanded and deformed, resulting in severe spermatogenic disorders. LDH was seen after 60 days of 200 μg injection of LRH-A_3 in histochemistry.