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目的探讨宁波地区女性生殖道支原体属感染现状及支原体属感染与不孕之间关系,及支原体属对抗菌药物的耐药特点,为临床治疗支原体属感染合理选择抗菌药物提供实验室依据。方法对在医院就诊的门诊和住院的1593例女性患者的生殖道分泌物标本进行支原体属的培养和药敏试验,支原体属检测采用法国生物梅里埃公司生产的IST试剂盒进行检测。结果 1593例女性患者中,共检测出支原体属787株,阳性率为49.4%,感染以解脲脲支原体(Uu)为主,占86.8%;361例不孕症女性阴道分泌物中分离出211株支原体属,阳性检出率为57.4%;药敏试验结果显示,普那霉素、交沙霉素、多西环素、四环素对Uu的抗菌活性最强,敏感率分别为99.4%、97.5%、97.5%和95.5%;喹诺酮类抗菌活性最弱;环丙沙星、左氧氟沙星的耐药率分别为83.2%和70.4%;人支原体(Mh)的耐药率均高于解脲脲支原体,特别是对大环内酯类抗菌药物,其耐药率高达83.3%。结论女性生殖道支原体属感染呈上升趋势,因此临床上合理应用抗菌药物和正确的治疗对降低抗菌药物耐药率,防止治疗后的复发具有非常重要的意义;女性生殖道支原体属感染是引起流产和不孕症的主要原因,由支原体属引起的流产和不孕症是可逆的,治愈后仍有机会恢复生育。
Objective To investigate the status of Mycoplasma infection in female genital tract and the relationship between Mycoplasma infection and infertility in Ningbo area and the characteristics of drug resistance of Mycoplasma to antibacterial drugs, so as to provide a laboratory basis for clinical treatment of Mycoplasma infection. Methods Mycoplasma culture and drug susceptibility tests were performed on genital secretions from 1593 female patients who were hospitalized and hospitalized. Mycoplasma was detected by the IST kit manufactured by BioMerieux, France. Results Among the 1593 female patients, 787 mycoplasma were detected, the positive rate was 49.4%. The infection was mainly Uu, accounting for 86.8%. Among the 361 women with vaginal secretions, 211 Mycoplasma strains, the positive detection rate was 57.4%; drug susceptibility test results showed that the antibacterial activity of pristinamycin, josamycin, doxycycline and tetracycline was the strongest, the sensitivity rates were 99.4% and 97.5 %, 97.5% and 95.5%, respectively. The quinolone antibacterial activity was the weakest. The drug resistance rates of ciprofloxacin and levofloxacin were 83.2% and 70.4%, respectively. The drug resistance rates of M. hominis were higher than that of U. urealyticum, Especially for macrolide antibacterial drugs, the resistance rate as high as 83.3%. Conclusion Mycoplasma genital tract infections in female genital tract is on the rise. Therefore, rational use of antimicrobial agents and correct treatment in clinical practice are of great significance to reduce the rate of antimicrobial resistance and prevent relapse after treatment. Mycoplasma genitalium infection is the cause of miscarriage And the main reason of infertility, caused by Mycoplasma genital abortion and infertility are reversible, still have the opportunity to cure after cure reproductive.