论文部分内容阅读
许多热带国家不考虑其他条件,仅仅由于资金及医疗力量的限制,就规定使用脊髓灰质炎口服疫苗,而不主张使用灭活疫苗。Drozdov 和 Cockburn 的试验表明,以血清阳转率来评价口服脊髓灰质炎疫苗效能时,温带国家所获结果通常是高的。而在热带国家不全然如此,有时阳转率高,但在另一些国家的结果则低。新加坡、南非、巴西、尼日利亚、阿尔及利亚和古巴报道的效果均不满意。对这些地区所获之血清阳转率低的原因,有各种各样的解释。
Many tropical countries, without regard to other conditions, require the use of oral polio vaccine instead of advocating the use of an inactivated vaccine, simply because of financial and medical constraints. Trials by Drozdov and Cockburn have shown that when seropositivity rates are used to assess the efficacy of oral polio vaccine, the results obtained in temperate countries are usually high. In the case of the tropical countries, however, this is not always the case, sometimes with high positive rates, but in others the result is low. The results reported by Singapore, South Africa, Brazil, Nigeria, Algeria and Cuba were not satisfactory. There are various explanations for the low prevalence of seroconversion in these areas.