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目的 :研究肺鳞癌中 p5 3蛋白、nm2 3蛋白以及耐多药基因MDR1产物P 糖蛋白 (P glycoproteinP gp)的表达及相互关系 ,探讨它们在肺鳞癌发展、预后及耐药中的作用。方法 :采用免疫组化SP法 ,对 40例肺鳞癌及其癌旁正常肺组织中 p5 3蛋白、nm2 3和P gp进行检测。 结果 :p5 3蛋白、nm2 3及P gp在肺鳞癌中表达率分别为5 2 5 %、45 0 %和 6 5 0 % ,明显高于癌旁正常组织 (P <0 0 0 1) ,三者都与患者预后显著负相关 (P <0 0 5 ) ,p5 3蛋白表达与分化程度负相关 (P <0 0 5 )。nm2 3与淋巴结转移正相关 (P <0 0 5 )。p5 3、nm2 3与临床分期相关 ,P gp与临床分期无关。三者之间无相关性 (P >0 0 5 )。结论 :p5 3蛋白、nm2 3、P gp在肺鳞癌的发展过程中起了重要作用 ,可以作为评价肺鳞癌患者预后的有效参数 ,三者之间可能无必然联系
OBJECTIVE: To study the expression of p5 3 protein, nm23 protein and P glycoprotein P gp in lung squamous cell carcinoma and their roles in the development, prognosis and drug resistance of lung squamous cell carcinoma . Methods: Immunohistochemical SP method was used to detect p5 3 protein, nm23 and P gp in 40 cases of lung squamous cell carcinoma and adjacent normal lung tissues. Results: The expression rates of p53, nm23 and Pgp in lung squamous cell carcinoma were 52.5%, 45.0% and 65.0%, respectively, which were significantly higher than those in normal tissues (P <0.01 01) All three were significantly and negatively correlated with the prognosis of patients (P <0.05). The expression of p5 3 was negatively correlated with the degree of differentiation (P <0.05). nm23 was positively correlated with lymph node metastasis (P <0.05). p5 3, nm2 3 and clinical stage, P gp has nothing to do with clinical stage. There was no correlation between the three (P> 0.05). CONCLUSION: The expression of p53, nm23 and Pgp play an important role in the development of squamous cell carcinoma and may be used as a useful parameter to evaluate the prognosis of patients with squamous cell carcinoma. There may not be any necessary relationship among them