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钙拮抗剂的血管扩张和抗血管收缩作用对各种组织的缺血性疾病有治疗效果。基础研究表明,这种抗缺血作用不仅依靠血流动力学效应,而且靠钙拮抗剂引起的组织细胞的能量保存。大量临床资料也证明了钙拮抗剂的器官保护作用,如降低冠心病患者的再梗率和死亡率,减轻脑出血后的神经系统损害,延迟动脉粥样硬化的发生、发展,以及拮抗肾小球前的血管收缩效应,防止某些药物引起的肾毒性。
The vasodilator and anti-vasoconstrictor effects of calcium antagonists have a therapeutic effect on ischemic diseases of various tissues. Basic research shows that this anti-ischemic effect relies not only on hemodynamic effects, but also on the energy conservation of tissue cells caused by calcium antagonists. A large number of clinical data also prove the organ protective effect of calcium antagonists, such as reducing the rate of reinfarction and mortality in patients with coronary heart disease, relieving the nervous system damage after cerebral hemorrhage, delaying the occurrence and development of atherosclerosis, Vasoconstriction effect before the ball, to prevent some drugs caused by nephrotoxicity.