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目的极化液联合胺碘酮治疗急性心肌梗死(AMI)伴新发房颤(AF)的评价临床疗效及安全性。方法将78例AMI后新发房颤的患者随机分为联合组42例,单独组36例。联合组极化液500ml静脉滴注,两组房颤发作时均给予静脉推注胺碘酮150mg负荷量后,继以维持量1.0～1.5mg/kg静脉滴入,15～30min未转复且心室率快者,追加一次胺碘酮1.5mg/kg,至房颤转复停止用药。观察12h内转复率、安全性,QT间期变化等。结果联合组2h内的转复率为19.0%(8/42),12h内的总转复率为88.1%(37/42)。单独组2h内的转复率为16.7%(6/36),12h内的总转复率为63.9%(23/36)。两组间2h以内转复率差异无统计学意义(P>0.05)。两组12h内的总转复率(88.1%:63.9%)差异有统计学意义(P<0.01)。两组用药前后未见严重不良反应。结论极化液联合胺碘酮治疗AMI伴新发AF安全有效。
Objective To evaluate the clinical efficacy and safety of the combination of amiodarone and amiodarone in the treatment of acute myocardial infarction (AMI) with new-onset atrial fibrillation (AF). Methods Seventy-eight patients with new-onset atrial fibrillation after AMI were randomly divided into the combined group of 42 patients and the single group of 36 patients. 500ml intravenous infusion of the combination group of polarized solution, two groups of atrial fibrillation were given intravenous amiodarone 150mg load, followed by the maintenance dose of 1.0 ~ 1.5mg / kg intravenous infusion, 15 ~ 30min did not recuperate Ventricular rate faster, an additional amiodarone 1.5mg / kg, to atrial fibrillation to stop medication. Observed within 12h recovery rate, safety, QT interval changes. Results In the combined group, the recovery rate was 19.0% (8/42) within 2 hours and 88.1% (37/42) within 12 hours. The rate of reversion was 16.7% (6/36) within 2 hours and 63.9% (23/36) within 12 hours. There was no significant difference in recovery rate within 2 hours between the two groups (P> 0.05). The total recovery rate within 12 hours (88.1% vs. 63.9%) was significantly different between the two groups (P <0.01). Two groups before and after treatment no serious adverse reactions. Conclusion Polaroid combined with amiodarone is safe and effective in the treatment of AMI with new onset of AF.