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血管内皮功能障碍是血管老化的早期病理改变之一,对动脉粥样硬化的发生发展起到非常重要的作用。老年性血管内皮功能障碍主要表现在内皮一氧化氮、前列环素和内皮衍生超极化因子等一系列内皮舒血管物质的生成减少或其生物利用度下降,而内皮素、血栓素和活性氧等一些内皮缩血管物质的生成或血管对这些物质的敏感性增加。另外,衰老导致的血管内皮修复能力减退也起到一定的作用。现就衰老对这些因素的影响及其分子机制作一概述。
Vascular endothelial dysfunction is one of the early pathological changes of vascular aging, plays an important role in the development of atherosclerosis. Senile endothelial dysfunction mainly in endothelial nitric oxide, prostacyclin and endothelial derived hyperpolarization factor and a series of endothelial vasodilator production decreased or decreased bioavailability, and endothelin, thromboxane and reactive oxygen species Some of the formation of endothelial vasoconstrictor substances or vascular sensitivity to these substances increased. In addition, the diminished vascular endothelial repair resulting from aging also plays a role. Now on the aging of these factors and their molecular mechanisms to make an overview.