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目的：研究不同地区影响艾滋病患者抗病毒的服药依从性的因素。方法：回顾性分析350例艾滋病患者的临床资料，挑出其中的服药依从性好的人群与服药依从性差的人群，并从治疗因素、药物治疗因素、社会人口学因素中筛选出对患者服药依从性的影响OR值大于1的因素。结果：这350例艾滋病患者中服药依从性好的为250例，服药依从性差的为100例，对患者服药依从性的影响OR值大于1的因素为医疗费用、心理健康程度、对抗病毒药物知识的了解程度、当地的医疗服务质量。结论：影响艾滋病患者抗病毒的服药依从性的因素很多，主要集中在服务质量和对相应治疗的知识了解上。AIDS，250 of them had good anti -viral medication compliance and 100 of them had bad anti -viral medication compliance ．The factors which caused the anti -viral medication compliance greater than 1 OR were medical expenses ， mental health level ， the knowledge of anti-viral drugs and the local quality of medical services ．Conclusion：There were many factors which affect the antiviral medication compli-ance．The focus should be mainly on the quality of service and knowledge of the relative treatment ．