目的　研究 quinacrine经不同途径给药的血药浓度 ,了解 quinacrine经阴道向子宫内给药绝育 (quinacrine女性非外科绝育法 )可能产生的毒副反应。方法　以兔为模拟对象 ,用荧光分析法分别测定宫腔内缓释给药、静脉、口服和输卵管内注射等 4种不同途径给quinacrine的血药浓度变化。结果　血药浓度峰值以静脉给药法最高 ,宫腔内缓释给药法最低。宫腔内缓释给药法的血药浓度水平接近其他给药方法血药浓度水平的残余浓度。血药浓度下降的起点静脉法在给药后立即产生 ,口服法在给药后 8h出现 ,输卵管内注射法见于给药后 4h ,而宫内缓释法则可维持到 7d。结论　从是否产生全身性的毒副反应的角度看 ,quinacrine宫腔内缓释给药法比口服法低 ,用于女性非外科手术绝育是安全的 Objective To study the concentration of quinacrine administered by different routes of administration and to understand the possible side effects of quinacrine transvaginal intrauterine insemination (quinacrine female non-surgical sterilization). Methods Rabbit was used as the simulation object, and the changes of serum concentration of quinacrine were determined by fluorescence analysis in four different ways: intrauterine administration, intravenous injection, oral administration and intra-tubal injection respectively. Results The peak value of plasma concentration was the highest in intravenous administration and the lowest in intrauterine administration. The intrauterine sustained release drug administration has a plasma concentration level close to that of other drug delivery methods at the plasma concentration level. The initial venous blood concentration decreased in the administration immediately after administration, oral administration occurred 8h after administration, tubal injection was found in 4h after administration, and intrauterine sustained release law can be maintained to 7d. Conclusions From the point of view of whether there is a systemic toxicity or not, quinacrine intrauterine sustained release method is lower than oral method and safe for female non-surgical sterilization